For complete demographics, clinical characteristics, and treatment parameters, please refer to Grover et al.  Briefly, a majority of patients were WLWH (n = 96, 67%) with median CD4 count of 481 cells/μL (interquartile range (IQR), 351-579 μL) and median time on ART of 84 months (IQR, 24–120 months). The median age of WLWH was 43.4 years, significantly younger than those without HIV infection at 53.9 years (p = 0.004). Patients who presented with stage I, II, III or IV disease accounted for 14.9, 60.6, 24.5, and 0% of the WLWH and 6.4, 51.1, 38.3, and 4.3% of the cohort without HIV (p = 0.04). Baseline hemoglobin significantly differed between WLWH and without HIV infection (p = 0.04), with 10.6 g/dL (95% confidence interval (CI), 9.2–12.1) and 11.3 g/dL (95% CI, 10.5–13), respectively. Treatment received by patients did not differ by HIV status, with WLWH receiving a median dose of 79.8 Gy (IQR, 74–79.8 Gy) and 58.3% (n = 56) receiving ≥4 cycles of chemotherapy and patients without HIV infection receiving 79.8 Gy (IQR, 68.8–79.8 Gy) and 53.2% receiving ≥4 cycles. OS at 2 years was 65.5% (95% confidence interval [CI] 56–73%) overall, 65.0% (95% CI 54–74%) for WLWH, and 66.0% (95% CI 49–79%) for patients without HIV infection.
Analysis at 5 years had a median follow-up time for all patients of 37.6 months (63.0 months for living patients). Five-year OS was 55.6% (95% CI, 46.6–63.7%) for all patients, 56.8% (95% CI, 40.0–70.5%) for patients without HIV infection, and 55.1% (95% CI, 44.2–64.7%) for WLWH (p = 0.732) (Fig. 1). On univariate analysis, baseline hemoglobin level > 10 g/dL was associated with better OS, while poorer OS was associated with higher initial stage at diagnosis (stage III and IV) and receipt of < 2 chemotherapy cycles (Table 1). After adjusting for HIV status, age, stage, number of chemotherapy cycles received, baseline hemoglobin, and total radiation dose (EQD2), multivariate analysis demonstrated that baseline hemoglobin ≥10 g/dL remained associated with improved survival and advanced stage (stage III and IV) remained associated with poorer survival (Table 1). Notably, neither univariate nor multivariate analyses found that HIV status was associated with poorer survival in this cohort.
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