Cohen A, Katholing A, Rietbrock S, Bamber L, Martinez C. Epidemiology of first and recurrent venous thromboembolism in patients with active cancer. A population-based cohort study. Thromb Haemost. 2017;117(1):57–65. https://doi.org/10.1160/TH15-08-0686.
Faiz AS, Khan I, Beckman MG, Bockenstedt P, Heit JA, Kulkarni R, et al. Characteristics and risk factors of Cancer associated venous thromboembolism. Thromb Res. 2015;136(3):535–41. https://doi.org/10.1016/j.thromres.2015.06.036.
Kourlaba G, Relakis J, Mylonas C, Kapaki V, Kontodimas S, Holm MV, et al. The humanistic and economic burden of venous thromboembolism in cancer patients: a systematic review. Blood Coagul Fibrinolysis. 2015;26(1):13–31. https://doi.org/10.1097/MBC.0000000000000193.
Mulder F, et al. Venous thromboembolism in cancer patients: a population-based cohort study. Blood. 2021;137(14):1959–69. https://doi.org/10.1182/blood.2020007338.
Khorana AA, et al. Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy. J Thromb Haemost. 2007;5(3):632–4. https://doi.org/10.1111/j.1538-7836.2007.02374.x.
Kuderer NM, Ortel TL, Francis CW. Impact of venous thromboembolism and anticoagulation on cancer and cancer survival. J Clin Oncol. 2009;27(29):4902–11. https://doi.org/10.1200/JCO.2009.22.4584.
Hutten BA, Prins MH, Gent M, Ginsberg J, Tijssen JGP, Büller HR. Incidence of recurrent thromboembolic and bleeding complications among patients with venous thromboembolism in relation to both malignancy and achieved international normalized ratio: a retrospective analysis. J Clin Oncol. 2000;18(17):3078–83. https://doi.org/10.1200/JCO.2000.18.17.3078.
Prandoni P, Lensing AWA, Piccioli A, Bernardi E, Simioni P, Girolami B, et al. Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis. Blood. 2002;100(10):3484–8. https://doi.org/10.1182/blood-2002-01-0108.
Di Minno MND, et al. Direct oral anticoagulants for the treatment of acute venous thromboembolism in patients with cancer: a meta-analysis of randomised controlled trials. Eur Respir J. 2017;50(3). https://doi.org/10.1183/13993003.01097-2017.
Marin-Barrera L, Muñoz-Martin AJ, Rios-Herranz E, Garcia-Escobar I, Beato C, Font C, et al. A Case-Control Analysis of the Impact of Venous Thromboembolic Disease on Quality of Life of Patients with Cancer: Quality of Life in Cancer (Qca) Study. Cancers (Basel). 2019;12(1). https://doi.org/10.3390/cancers12010075.
Khorana AA, et al. Health care costs associated with venous thromboembolism in selected high-risk ambulatory patients with solid tumors undergoing chemotherapy in the United States. Clinicoecon Outcomes Res. 2013;5:101–8. https://doi.org/10.2147/CEOR.S39964.
Connolly GC, Dalal M, Lin J, Khorana AA. Incidence and predictors of venous thromboembolism (VTE) among ambulatory patients with lung cancer. Lung Cancer. 2012;78(3):253–8. https://doi.org/10.1016/j.lungcan.2012.09.007.
Streiff M, Milentijevic D, McCrae KR, Laliberté F, Lejeune D, Lefebvre P, et al. Healthcare resource utilization and costs associated with venous thromboembolism in cancer patients treated with anticoagulants. J Med Econ. 2019;22(11):1134–40. https://doi.org/10.1080/13696998.2019.1620752.
Lyman GH, Bohlke K, Khorana AA, Kuderer NM, Lee AY, Arcelus JI, et al. Venous thromboembolism prophylaxis and treatment in patients with cancer: american society of clinical oncology clinical practice guideline update 2014. J Clin Oncol. 2015;33(6):654–6. https://doi.org/10.1200/JCO.2014.59.7351.
Farge D, Bounameaux H, Brenner B, Cajfinger F, Debourdeau P, Khorana AA, et al. International clinical practice guidelines including guidance for direct oral anticoagulants in the treatment and prophylaxis of venous thromboembolism in patients with cancer. Lancet Oncol. 2016;17(10):e452–66. https://doi.org/10.1016/S1470-2045(16)30369-2.
Etxeandia-Ikobaltzeta I, Zhang Y, Brundisini F, Florez ID, Wiercioch W, Nieuwlaat R, et al. Patient values and preferences regarding VTE disease: a systematic review to inform American Society of Hematology guidelines. Blood Adv. 2020;4(5):953–68. https://doi.org/10.1182/bloodadvances.2019000462.
Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361(12):1139–51. https://doi.org/10.1056/NEJMoa0905561.
Granger CB, Alexander JH, McMurray JJV, Lopes RD, Hylek EM, Hanna M, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365(11):981–92. https://doi.org/10.1056/NEJMoa1107039.
Patel MR, Mahaffey KW, Garg J, Pan G, Singer DE, Hacke W, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011;365(10):883–91. https://doi.org/10.1056/NEJMoa1009638.
Giugliano RP, Ruff CT, Braunwald E, Murphy SA, Wiviott SD, Halperin JL, et al. Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2013;369(22):2093–104. https://doi.org/10.1056/NEJMoa1310907.
Key NS, Khorana AA, Kuderer NM, Bohlke K, Lee AYY, Arcelus JI, et al. Venous thromboembolism prophylaxis and treatment in patients with Cancer: ASCO clinical practice guideline update. J Clin Oncol. 2020;38(5):496–520. https://doi.org/10.1200/JCO.19.01461.
Streiff MB, Abutalib SA, Farge D, Murphy M, Connors JM, Piazza G. Update on guidelines for the Management of Cancer-Associated Thrombosis. Oncologist. 2021;26(1):e24–40. https://doi.org/10.1002/onco.13596.
Kimpton M, Carrier M. Efficacy and safety of Xa inhibitors for the treatment of cancer-associated venous thromboembolism. Expert Opin Drug Saf. 2019;18(4):313–20. https://doi.org/10.1080/14740338.2019.1601699.
Lopes DG, Tamayo A, Schipp B, Siepmann T. Cost-effectiveness of edoxaban vs low-molecular-weight heparin and warfarin for cancer-associated thrombosis in Brazil. Thromb Res. 2020;196:4–10. https://doi.org/10.1016/j.thromres.2020.08.014.
de Jong LA, van der Velden AWG, Hulst M, Postma MJ. Cost-effectiveness analysis and budget impact of rivaroxaban compared with dalteparin in patients with cancer at risk of recurrent venous thromboembolism. BMJ Open. 2020;10(11):e039057. https://doi.org/10.1136/bmjopen-2020-039057.
Li A, Manohar PM, Garcia DA, Lyman GH, Steuten LM. Cost effectiveness analysis of direct oral anticoagulant (DOAC) versus dalteparin for the treatment of cancer associated thrombosis (CAT) in the United States. Thromb Res. 2019;180:37–42. https://doi.org/10.1016/j.thromres.2019.05.012.
Connell NT, Connors JM. Cost-effectiveness of edoxaban versus dalteparin for the treatment of cancer-associated thrombosis. J Thromb Thrombolysis. 2019;48(3):382–6. https://doi.org/10.1007/s11239-019-01903-z.
Howlett J, Benzenine E, Fagnoni P, Quantin C. Are direct oral anticoagulants an economically attractive alternative to low molecular weight heparins in lung cancer associated venous thromboembolism management? J Thromb Thrombolysis. 2020;50(3):642–51. https://doi.org/10.1007/s11239-020-02047-1.
Al Mukdad M, Al-Badriyeh D, Elewa HF. Cost-effectiveness Evaluations Among the Direct Oral Anticoagulants for the Prevention and Treatment of Venous Thromboembolism: Systematic Review. Clin Appl Thromb Hemost. 2019;25:1076029619849103.
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7–34. https://doi.org/10.3322/caac.21551.
Miller KD, Siegel RL, Lin CC, Mariotto AB, Kramer JL, Rowland JH, et al. Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 2016;66(4):271–89. https://doi.org/10.3322/caac.21349.
Lui FH, Tuan B, Swenson SL, Wong RJ. Ethnic disparities in gastric cancer incidence and survival in the USA: an updated analysis of 1992-2009 SEER data. Dig Dis Sci. 2014;59(12):3027–34. https://doi.org/10.1007/s10620-014-3275-3.
Raskob GE, Büller HR, Segers A. Edoxaban for Cancer-associated venous thromboembolism. N Engl J Med. 2018;379(1):95–6. https://doi.org/10.1056/NEJMc1806646.
Young AM, Marshall A, Thirlwall J, Chapman O, Lokare A, Hill C, et al. Comparison of an Oral factor Xa inhibitor with low molecular weight heparin in patients with Cancer with venous thromboembolism: results of a randomized trial (SELECT-D). J Clin Oncol. 2018;36(20):2017–23. https://doi.org/10.1200/JCO.2018.78.8034.
Agnelli G, Becattini C, Meyer G, Muñoz A, Huisman MV, Connors JM, et al. Apixaban for the treatment of venous thromboembolism associated with Cancer. N Engl J Med. 2020;382(17):1599–607. https://doi.org/10.1056/NEJMoa1915103.
McBane RD 2nd, et al. Apixaban and dalteparin in active malignancy-associated venous thromboembolism: the ADAM VTE trial. J Thromb Haemost. 2020;18(2):411–21. https://doi.org/10.1111/jth.14662.
Chee C, et al. Predictors of venous thromboembolism recurrence and bleeding among active cancer patients: a population-based cohort study. Blood. 2014;123(25):3972–8. https://doi.org/10.1182/blood-2014-01-549733.
Chinese drug price of drug centralized bid procurement. Chinese drug price of drug centralized bid procurement Accessed 19 February 2021 19 February 2021; Available from: Available from: https://db.yaozh.com/yaopinzhongbiao.
Du J, Wu B. New Oral anticoagulants for Thromboprophylaxis in patients with Cancer receiving chemotherapy: an economic evaluation in a Chinese setting. Clin Drug Investig. 2020;40(7):653–63. https://doi.org/10.1007/s40261-020-00926-2.
Zhou JS, Bao-Jin LI. Cost-effectiveness analysis of endoscope and Omprazole in the treatment of acute hemorrhage of upper digestive tract. Lingnan J Emerg Med. 2013.
Yang L, Wu J. Cost-effectiveness of rivaroxaban compared with enoxaparin plus warfarin for the treatment of hospitalised acute deep vein thrombosis in China. BMJ Open. 2020;10(7):e038433. https://doi.org/10.1136/bmjopen-2020-038433.
Locadia M, Bossuyt PM, Stalmeier PF, Sprangers MA, van Dongen C, Middeldorp S, et al. Treatment of venous thromboembolism with vitamin K antagonists: patients’ health state valuations and treatment preferences. Thromb Haemost. 2004;92(6):1336–41. https://doi.org/10.1160/TH04-02-0075.
Büller H, et al. Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism. N Engl J Med. 2013;369(15):1406–15. https://doi.org/10.1056/NEJMoa1306638.
Preblick R, et al. Cost-effectiveness of edoxaban for the treatment of venous thromboembolism based on the Hokusai-VTE study. Hosp Pract (1995). 2015;43(5):249–57.
Wang X, et al. Guideline for postmarketing Chinese medicine pharmacoeconomic evaluation. Chin J Integr Med. 2015;21(6):473–80. https://doi.org/10.1007/s11655-014-1749-y.
Jankovic SM, Milovanovic DR. Cost and utility of a low-molecular-weight heparin and unfractionated heparin for treatment of deep venous thrombosis in a Balkan country: a model analysis. Exp Clin Cardiol. 2006;11(2):111–6.
Marshall A, Levine M, Hill C, Hale D, Thirlwall J, Wilkie V, et al. Treatment of cancer-associated venous thromboembolism: 12-month outcomes of the placebo versus rivaroxaban randomization of the SELECT-D trial (SELECT-D: 12m). J Thromb Haemost. 2020;18(4):905–15. https://doi.org/10.1111/jth.14752.
Bertram M, et al. Cost-effectiveness thresholds: pros and cons. Bull World Health Organ. 2016;94(12):925–30. https://doi.org/10.2471/BLT.15.164418.
Sullivan S, et al. Measuring the outcomes and pharmacoeconomic consequences of venous thromboembolism prophylaxis in major orthopaedic surgery. PharmacoEconomics. 2003;21(7):477–96. https://doi.org/10.2165/00019053-200321070-00003.
McCullagh L, Walsh C, Barry M. Value-of-information analysis to reduce decision uncertainty associated with the choice of thromboprophylaxis after total hip replacement in the Irish healthcare setting. PharmacoEconomics. 2012;30(10):941–59. https://doi.org/10.2165/11591510-000000000-00000.
Wolowacz S, et al. Economic evaluation of dabigatran etexilate for the prevention of venous thromboembolism after total knee and hip replacement surgery. Clin Ther. 2009;31(1):194–212. https://doi.org/10.1016/j.clinthera.2009.01.001.
Botteman M, Caprini J, Stephens JM, Nadipelli V, Bell CF, Pashos CL, et al. Results of an economic model to assess the cost-effectiveness of enoxaparin, a low-molecular-weight heparin, versus warfarin for the prophylaxis of deep vein thrombosis and associated long-term complications in total hip replacement surgery in the United States. Clin Ther. 2002;24(11):1960–86; discussion 1938. https://doi.org/10.1016/s0149-2918(02)80091-1.
Diamantopoulos A, Lees M, Wells P, Forster F, Ananthapavan J, McDonald H. Cost-effectiveness of rivaroxaban versus enoxaparin for the prevention of postsurgical venous thromboembolism in Canada. Thromb Haemost. 2010;104(4):760–70. https://doi.org/10.1160/TH10-01-0071.
Ryttberg L, Diamantopoulos A, Forster F, Lees M, Fraschke A, Björholt I. Cost-effectiveness of rivaroxaban versus heparins for prevention of venous thromboembolism after total hip or knee surgery in Sweden. Expert Rev Pharmacoecon Outcomes Res. 2011;11(5):601–15. https://doi.org/10.1586/erp.11.65.
Gordois A, Posnett J, Borris L, Bossuyt P, Jonsson B, Levy E, et al. The cost-effectiveness of fondaparinux compared with enoxaparin as prophylaxis against thromboembolism following major orthopedic surgery. J Thromb Haemost. 2003;1(10):2167–74. https://doi.org/10.1046/j.1538-7836.2003.00396.x.
Chen DY, Tseng CN, Hsieh MJ, Lan WC, Chuang CK, Pang ST, et al. Comparison between non-vitamin K antagonist Oral anticoagulants and low-molecular-weight heparin in Asian individuals with Cancer-associated venous thromboembolism. JAMA Netw Open. 2021;4(2):e2036304. https://doi.org/10.1001/jamanetworkopen.2020.36304.
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