• Mukherjee PK, Harwansh RK, Bahadur S, Banerjee S, Kar A, Chanda J, Biswas S, Ahmmed SM, Katiyar CK. Development of Ayurveda – Tradition to trend. J Ethnopharmacol. 2017;197:10–24.

    PubMed 
    Article 

    Google Scholar
     

  • Balachandran P, Govindarajan R. Cancer–an ayurvedic perspective. Pharmacol Res. 2005;51(1):19–30.

    PubMed 
    Article 

    Google Scholar
     

  • Saper RB, Kales SN, Paquin J, Burns MJ, Eisenberg DM, Davis RB, Phillips RS. Heavy Metal Content of Ayurvedic Herbal Medicine Products. JAMA. 2004;292(23):2868–73.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Deocaris CC, Widodo N, Wadhwa R, Kaul SC. Merger of Ayurveda and tissue culture-based functional genomics: inspirations from systems biology. J Transl Med. 2008;6:14.

    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar
     

  • Paul M, Davey B, Senf B, Stoll C, Munstedt K, Mucke R, Micke O, Prott FJ, Buentzel J, Hubner J. Patients with advanced cancer and their usage of complementary and alternative medicine. J Cancer Res Clin Oncol. 2013;139(9):1515–22.

    PubMed 
    Article 

    Google Scholar
     

  • Kumar D, Goel NK, Pandey AK, Sarpal SS. Complementary and alternative medicine use among the cancer patients in Northern India. South Asian Journal of Cancer. 2016;5:8–11.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Wilken R, Veena MS, Wang MB, Srivatsan ES. Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol Cancer. 2011;10:12.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Mohankumar K, Pajaniradje S, Sridharan S, Singh VK, Ronsard L, Banerjea AC, Selvanesan BC, Coumar MS, Periyasamy L, Rajagopalan R. Apoptosis induction by an analog of curcumin (BDMC-A) in human laryngeal carcinoma cells through intrinsic and extrinsic pathways. Cell Oncol (Dordr). 2014;37(6):439–54.

    CAS 
    Article 

    Google Scholar
     

  • Subramani R, Gonzalez E, Arumugam A, Nandy S, Gonzalez V, Medel J, Camacho F, Ortega A, Bonkoungou S, Narayan M, et al. Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition. Sci Rep. 2016;6:19819.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Subramani R, Gonzalez E, Nandy SB, Arumugam A, Camacho F, Medel J, Alabi D, Lakshmanaswamy R. Gedunin inhibits pancreatic cancer by altering sonic hedgehog signaling pathway. Oncotarget. 2017;8:10891–904.

    PubMed 
    Article 

    Google Scholar
     

  • Mao X, Wu LF, Guo HL, Chen WJ, Cui YP, Qi Q, Li S, Liang WY, Yang GH, Shao YY, et al. The Genus Phyllanthus: An ethnopharmacological, phytochemical, and pharmacological review. Evid Based Complement Alternat Med. 2016;2016:7584952.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhao T, Sun Q, Marques M, Witcher M. Anticancer properties of Phyllanthus emblica (Indian Gooseberry). Oxid Med Cell Longev. 2015;2015:950890.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Duangmano S, Sae-lim P, Suksamrarn A, Domann FE, Patmasiriwat P. Cucurbitacin B inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin B23 translocation. BMC Complementary and Alternative Medicine. 2012;12:185.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Wang X, Tanaka M, Peixoto HS, Wink M. Cucurbitacins: elucidation of their interactions with the cytoskeleton. PeerJ. 2017;5:e3357.

    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar
     

  • Cao YY, Yu J, Liu TT, Yang KX, Yang LY, Chen Q, Shi F, Hao JJ, Cai Y, Wang MR, et al. Plumbagin inhibits the proliferation and survival of esophageal cancer cells by blocking STAT3-PLK1-AKT signaling. Cell Death Dis. 2018;9(2):17.

    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar
     

  • Thornburg CC, Britt JR, Evans JR, Akee RK, Whitt JA, Trinh SK, Harris MJ, Thompson JR, Ewing TL, Shipley SM, et al. NCI program for natural product discovery: A publicly-accessible library of natural product fractions for high-throughput screening. ACS Chem Biol. 2018;13(9):2484–97.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Holbeck SL. Update on NCI in vitro drug screen utilities. Eur J Cancer. 2004;40(6):785–93.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Holbeck SL, Collins JM, Doroshow JH. Analysis of Food and Drug Administration-approved anticancer agents in the NCI60 panel of human tumor cell lines. Mol Cancer Ther. 2010;9(5):1451–60.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Shoemaker RH. The NCI60 human tumour cell line anticancer drug screen. Nat Rev. 2006;6:813–23.

    CAS 
    Article 

    Google Scholar
     

  • Kohn KW, Zeeberg BR, Reinhold WC, Sunshine M, Luna A, Pommier Y. Gene expression profiles of the NCI-60 human tumor cell lines define molecular interaction networks governing cell migration processes. PLoS ONE. 2012;7(5):e35716.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Monks A, Zhao Y, Hose C, Hamed H, Krushkal J, Fang J, Sonkin D, Palmisano A, Polley EC, Fogli LK, et al. The NCI Transcriptional Pharmacodynamics Workbench: A tool to examine dynamic expression profiling of therapeutic response in the NCI-60 cell line panel. Cancer Res. 2018;78(24):6807–17.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Reinhold WC, Sunshine M, Liu H, Varma S, Kohn KW, Morris J, Doroshow J, Pommier Y. Cell Miner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set. Cancer Res. 2012;72(14):3499–511.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Luna A, Elloumi F, Varma S, Wang Y, Rajapakse VN, Aladjem MI, Robert J, Sander C, Pommier Y, Reinhold WC. CellMiner Cross-Database (CellMinerCDB) version 1.2: Exploration of patient-derived cancer cell line pharmacogenomics. Nucleic Acids Res. 2020;49(D1):D1083–93.

    PubMed Central 
    Article 
    CAS 

    Google Scholar
     

  • Paull KD, Shoemaker RH, Hodes L, Monks A, Scudiero DA, Rubinstein L, Plowman J, Boyd MR. Display and analysis of patterns of differential activity of drugs against human tumor cell lines: Development of mean graph and COMPARE algorithm. Journal of National Cancer Institute. 1989;81:1088–92.

    CAS 
    Article 

    Google Scholar
     

  • Zaharevitz DW, Holbeck SL, Bowerman C, Svetlik PA. COMPARE: a web accessible tool for investigating mechanisms of cell growth inhibition. J Mol Graph Model. 2002;20:297–303.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Paradis E, Schliep K. ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R. Bioinformatics. 2019;35:526–8.

  • Huson DH, Scornavacca C. Dendroscope 3: an interactive tool for rooted phylogenetic trees and networks. Syst Biol. 2012;61(6):1061–7.

    PubMed 
    Article 

    Google Scholar
     

  • Rajapakse VN, Luna A, Yamade M, Loman L, Varma S, Sunshine M, Iorio F, Sousa FG, Elloumi F, Aladjem MI, et al. CellMinerCDB for integrative cross-database genomics and pharmacogenomics analyses of cancer cell lines. iScience. 2018;10:247–64.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Krushkal J, Negi S, Yee LM, Evans JR, Grkovic T, Palmisano A, Fang J, Sankaran H, McShane LM, Zhao Y, et al. Molecular genomic features associated with in vitro response of the NCI-60 cancer cell line panel to natural products. Molecular Oncology. 2021;15:381–406.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Raudvere U, Kolberg L, Kuzmin I, Arak T, Adler P, Peterson H, Vilo J. g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update). Nucleic Acids Res. 2019;47(W1):W191–8.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Abaan OD, Polley EC, Davis SR, Zhu YJ, Bilke S, Walker RL, Pineda M, Gindin Y, Jiang Y, Reinhold WC, et al. The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology. Cancer Res. 2013;73(14):4372–82.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Chakravarty D, Gao J, Phillips S, Kundra R, Zhang H. OncoKB: A Precision Oncology Knowledge Base. JCO Precis Oncol. 2017;2017:PO.17.00011.


    Google Scholar
     

  • Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498–504.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Chan J, Khan SN, Harvey I, Merrick W, Pelletier J. Eukaryotic protein synthesis inhibitors identified by comparison of cytotoxicity profiles. RNA. 2004;10(3):528–43.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Saraswati S, Kanaujia PK, Kumar S, Kumar R, Alhaider AA. Tylophorine, a phenanthraindolizidine alkaloid isolated from Tylophora indica exerts antiangiogenic and antitumor activity by targeting vascular endothelial growth factor receptor 2–mediated angiogenesis. Mol Cancer. 2013;12:82.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Wu CM, Yang CW, Lee YZ, Chuang TH, Wu PL, Chao YS, Lee SJ. Tylophorine arrests carcinoma cells at G1 phase by downregulating cyclin A2 expression. Biochem Biophys Res Commun. 2009;386(1):140–5.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Sharbeen G, McCarroll JA, Akerman A, Kopecky C, Youkhana J, Kokkinos J, Holst J, Boyer C, Erkan M, Goldstein D, et al. Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition. Cancer Res. 2021;81(13):3461–79.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Huang Y, Dai Z, Barbacioru C, Sadee W. Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance. Cancer Res. 2005;65(16):7446–54.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Liu R, Blower PE, Pham AN, Fang J, Dai Z, Wise C, Green B, Teitel CH, Ning B, Ling W, et al. Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin. Mol Pharmacol. 2007;72(6):1637–46.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Badgley MA, Kremer DM, Maurer HC, DelGiorno KE, Lee HJ, Purohit V, Sagalovskiy IR, Ma A, Kapilian J, Firl CEM, et al. Cysteine depletion induces pancreatic tumor ferroptosis in mice. Science. 2020;368(6486):85–9.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, Koppula P, Wu S, Zhuang L, Fang B, et al. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature. 2021;593(7860):586–90.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Hu K, Li K, Lv J, Feng J, Chen J, Wu H, Cheng F, Jiang W, Wang J, Pei H, et al. Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma. J Clin Invest. 2020;130(4):1752–66.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Koppula P, Zhuang L, Gan B. Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient
    dependency, and cancer therapy. Protein Cell. 2020;12(8):599–620.

    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar
     

  • Liu DS, Duong CP, Haupt S, Montgomery KG, House CM, Azar WJ, Pearson HB, Fisher OM, Read M, Guerra GR, et al. Inhibiting the system xC(-)/glutathione axis selectively targets cancers with mutant-p53 accumulation. Nat Commun. 2017;8:14844.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Merle N, Feraud O, Gilquin B, Hubstenberger A, Kieffer-Jacquinot S, Assard N, Bennaceur-Griscelli A, Honnorat J, Baudier J. ATAD3B is a human embryonic stem cell specific mitochondrial protein, re-expressed in cancer cells, that functions as dominant negative for the ubiquitous ATAD3A. Mitochondrion. 2012;12(4):441–8.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Liu X, Li G, Ai L, Ye Q, Yu T, Yang B. Prognostic value of ATAD3 gene cluster expression in hepatocellular carcinoma. Oncol Lett. 2019;18(2):1304–10.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lim HW, Lim HY, Wong KP. Uncoupling of oxidative phosphorylation by curcumin: implication of its cellular mechanism of action. Biochem Biophys Res Commun. 2009;389(1):187–92.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Ramsay RG, Gonda TJ. MYB function in normal and cancer cells. Nat Rev Cancer. 2008;8(7):523–34.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Wu S, Lu H, Bai Y. Nrf2 in cancers: A double-edged sword. Cancer Med. 2019;8(5):2252–67.

    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Panieri E, Buha A, Telkoparan-Akillilar P, Cevik D, Kouretas D, Veskoukis A, Skaperda Z, Tsatsakis A, Wallace D, Suzen S, et al. Potential applications of NRF2 modulators in cancer therapy. Antioxidants (Basel). 2020;9(3):93.


    Google Scholar
     

  • Chamcheu JC, Roy T, Uddin MB, Banang-Mbeumi S, Chamcheu RN, Walker AL, Liu YY, Huang S. Role and therapeutic targeting of the PI3K/Akt/mTOR signaling pathway in skin cancer: A review of current status and future trends on natural and synthetic agents therapy. Cells. 2019;8(8):803.

    CAS 
    PubMed Central 
    Article 

    Google Scholar
     

  • Borges GA, Elias ST, Amorim B, de Lima CL, Coletta RD, Castilho RM, Squarize CH, Guerra ENS. Curcumin downregulates the PI3K-AKT-mTOR pathway and inhibits growth and progression in head and neck cancer cells. Phytother Res. 2020;34(12):3311–24.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Silvera D, Formenti SC, Schneider RJ. Translational control in cancer. Nat Rev Cancer. 2010;10(4):254–66.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Chakravarti N, Kadara H, Yoon DJ, Shay JW, Myers JN, Lotan D, Sonenberg N, Lotan R. Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells. Cancer Prev Res (Phila). 2010;3(3):331–8.

    CAS 
    Article 

    Google Scholar
     

  • Gara RK, Kumari S, Ganju A, Yallapu MM, Jaggi M, Chauhan SC. Slit/Robo pathway: a promising therapeutic target for cancer. Drug Discov Today. 2015;20(1):156–64.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Tong R, Wu X, Liu Y, Liu Y, Zhou J, Jiang X, Zhang L, He X, Ma L. Curcumin-induced DNA demethylation in human gastric cancer cells is mediated by the DNA-damage response pathway. Oxid Med Cell Longev. 2020;2020:2543504.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Flaherty KT, Infante JR, Daud A, Gonzalez R, Kefford RF, Sosman J, Hamid O, Schuchter L, Cebon J, Ibrahim N, et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med. 2012;367(18):1694–703.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Zhang J, Song Y, Liang Y, Zou H, Zuo P, Yan M, Jing S, Li T, Wang Y, Li D, et al. Cucurbitacin IIa interferes with EGFR-MAPK signaling pathway leads to proliferation inhibition in A549cells. Food Chem Toxicol. 2019;132:110654.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Patra S, Pradhan B, Nayak R, Behera C, Rout L, Jena M, Efferth T, Bhutia SK. Chemotherapeutic efficacy of curcumin and resveratrol against cancer:
    Chemoprevention, chemoprotection, drug synergism and clinical pharmacokinetics. Semin Cancer Biol. 2020;73:310–20.

    PubMed 
    Article 
    CAS 

    Google Scholar
     

  • Mohammed SA, Ambrosini S, Luscher T, Paneni F, Costantino S. Epigenetic control of mitochondrial function in the vasculature. Front Cardiovasc Med. 2020;7:28.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Desai R, Campanella M. Exploring mitochondrial cholesterol signalling for therapeutic intervention in neurological conditions. Br J Pharmacol. 2019;176(22):4284–92.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Li S, Bouzar C, Cottet-Rousselle C, Zagotta I, Lamarche F, Wabitsch M, Tokarska-Schlattner M, Fischer-Posovszky P, Schlattner U, Rousseau D. Resveratrol inhibits lipogenesis of 3T3-L1 and SGBS cells by inhibition of insulin signaling and mitochondrial mass increase. Biochim Biophys Acta. 2016;1857(6):643–52.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Fang HY, Chang CL, Hsu SH, Huang CY, Chiang SF, Chiou SH, Huang CH, Hsiao YT, Lin TY, Chiang IP, et al. ATPase family AAA domain-containing 3A is a novel anti-apoptotic factor in lung adenocarcinoma cells. J Cell Sci. 2010;123(Pt 7):1171–80.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Gires O, Munz M, Schaffrik M, Kieu C, Rauch J, Ahlemann M, Eberle D, Mack B, Wollenberg B, Lang S, et al. Profile identification of disease-associated humoral antigens using AMIDA, a novel proteomics-based technology. Cell Mol Life Sci. 2004;61(10):1198–207.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Sorokina M, Steinbeck C. Review on natural products databases: where to find data in 2020. J Cheminform. 2020;12(1):20.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Manga M, Sagar P, Singh H, Raghava GP, Agarwal SM. NPACT: Naturally Occurring Plant-based Anti-cancer
    Compound-Activity-Target database. Nucleic Acids Res. 2013;41(Database issue):D1124-1129.

    Article 
    CAS 

    Google Scholar
     

  • Mohanraj K, Karthikeyan BS, Vivek-Ananth RP, Chand RPB, Aparna SR, Mangalapandi P, Samal A. IMPPAT: A curated database of Indian Medicinal Plants, Phytochemistry And Therapeutics. Sci Rep. 2018;8(1):4329.

    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar
     

  • Marx KA, O’Neil P, Hoffman P, Ujwal ML. Data mining the NCI cancer cell line compound GI50 values: Identifying quinone subtypes effective against melanoma and leukemia cell classes. J Chem Inf Comput Sci. 2003;43:1652–67.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Scherf U, Ross DT, Waltham M, Smith LH, Lee JK, Tanabe L, Kohn K, Reinhold WC, Myers TG, Andrews DT, et al. A gene expression database for the molecular pharmacology of cancer. Nat Genet. 2000;24:236–44.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Weinstein JN, Pommier Y. Transcriptomic analysis of the NCI-60 cancer cell lines. C R Biol. 2003;326(10–11):909–20.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

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