• Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014;55(4):475–82.

    Article 

    Google Scholar
     

  • Thijs RD, Surges R, O’Brien TJ, Sander JW. Epilepsy in adults. The Lancet. 2019;393(10172):689–701.

    Article 

    Google Scholar
     

  • Shin EJ, Jeong JH, Chung YH, Kim WK, Ko KH, Bach JH, et al. Role of oxidative stress in epileptic seizures. Neurochem Int. 2011;59(2):122–37.

    CAS 
    Article 

    Google Scholar
     

  • Aguiar CC, Almeida AB, Araújo PV, Abreu RN, Chaves EM, Vale OC, et al. Oxidative stress and epilepsy: literature review. Oxid Med Cell Longev. 2012;2012: 795259. https://doi.org/10.1155/2012/795259.

    CAS 
    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Vezzani A, Aronica E, Mazarati A, Pittman QJ. Epilepsy and brain inflammation. Exp Neurol. 2013;1(244):11–21.

    Article 

    Google Scholar
     

  • Fujii H, Nakai K, Fukagawa M. Role of oxidative stress and indoxyl sulfate in progression of cardiovascular disease in chronic kidney disease. Ther Apher Dial. 2011;15(2):125–8.

    CAS 
    Article 

    Google Scholar
     

  • Small DM, Coombes JS, Bennett N, Johnson DW, Gobe GC. Oxidative stress, anti-oxidant therapies and chronic kidney disease. Nephrology. 2012;17(4):311–21.

    CAS 
    Article 

    Google Scholar
     

  • Yasui K, Baba A. Therapeutic potential of superoxide dismutase (SOD) for resolution of inflammation. Inflamm Res. 2006;55(9):359–63.

    CAS 
    Article 

    Google Scholar
     

  • Mirończuk-Chodakowska I, Witkowska AM, Zujko ME. Endogenous non-enzymatic antioxidants in the human body. Adv Med Sci. 2018;63(1):68–78.

    Article 

    Google Scholar
     

  • Al-Muhammadi MO, Al-Tameemi KM, Kadhim HM. Role of superoxide dismutase enzyme in patients with epilepsy. Med J Babylon. 2015;12(4):1015–9.


    Google Scholar
     

  • Guler SK, Aytac B, Durak ZE, Cokal BG, Gunes N, Durak I, et al. Antioxidative–oxidative balance in epilepsy patients on antiepileptic therapy: a prospective case–control study. Neurol Sci. 2016;37(5):763–7.

    Article 

    Google Scholar
     

  • Prasad DK, Satyanarayana U, Shaheen U, Prabha TS, Munshi A. Oxidative stress in the development of genetic generalised epilepsy: an observational study in southern Indian population. J Clin Diagn Res JCDR. 2017;11(9):BC05.

    CAS 
    PubMed 

    Google Scholar
     

  • Yoshida Y, Umeno A, Shichiri M. Lipid peroxidation biomarkers for evaluating oxidative stress and assessing antioxidant capacity in vivo. J Clin Biochem Nutr. 2013;52(1):9–16.

    CAS 
    Article 

    Google Scholar
     

  • Ayala A, Muñoz MF, Argüelles S. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev. 2014;2014: 360438. https://doi.org/10.1155/2014/360438.

    CAS 
    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nigar S, Pottoo FH, Tabassum N, Verma SK, Javed MN. Molecular insights into the role of inflammation and oxidative stress in epilepsy. J Adv Med Pharm Sci. 2016;10(1):1–9. https://doi.org/10.9734/JAMPS/2016/24441.

    Article 

    Google Scholar
     

  • Wong-Ekkabut J, Xu Z, Triampo W, Tang IM, Tieleman DP, Monticelli L. Effect of lipid peroxidation on the properties of lipid bilayers: a molecular dynamics study. Biophys J. 2007;93(12):4225–36.

    CAS 
    Article 

    Google Scholar
     

  • Sapkota M, Wyatt TA. Alcohol, aldehydes, adducts and airways. Biomolecules. 2015;5(4):2987–3008.

    CAS 
    Article 

    Google Scholar
     

  • Menon B, Ramalingam K, Kumar RV. Oxidative stress in patients with epilepsy is independent of antiepileptic drugs. Seizure. 2012;21(10):780–4.

    Article 

    Google Scholar
     

  • Das A, Sarwar MS, Hossain MS, Karmakar P, Islam MS, Hussain ME, et al. Elevated serum lipid peroxidation and reduced vitamin C and trace element concentrations are correlated with Epilepsy. Clin EEG Neurosci. 2019;50(1):63–72.

    Article 

    Google Scholar
     

  • Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, et al. Operational classification of seizure types by the international league against epilepsy: position paper of the ILAE commission for classification and terminology. Epilepsia. 2017;58(4):522–30.

    Article 

    Google Scholar
     

  • Scheffer IE, Berkovic S, Capovilla G, Connolly MB, French J, Guilhoto L, et al. ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58(4):512–21.

    Article 

    Google Scholar
     

  • Kwan P, Arzimanoglou A, Berg AT, Brodie MJ, Allen Hauser W, Mathern G, et al. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies [published correction appears in Epilepsia. 2010 Sep; 51(9):1922]. Epilepsia. 2010;51(6):1069–77. https://doi.org/10.1111/j.1528-1167.2009.02397.x.

    CAS 
    Article 
    PubMed 

    Google Scholar
     

  • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95(2):351–8.

    CAS 
    Article 

    Google Scholar
     

  • Nishikimi M, Rao NA, Yagi K. The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem Biophys Res Commun. 1972;46(2):849–54.

    CAS 
    Article 

    Google Scholar
     

  • Pauletti A, Terrone G, Shekh-Ahmad T, Salamone A, Ravizza T, Rizzi M, et al. Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy. Brain. 2019;142(7): e39. https://doi.org/10.1093/brain/awz130.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Simonato M, Agoston DV, Brooks-Kayal A, Dulla C, Fureman B, Henshall DC, et al. Identification of clinically relevant biomarkers of epileptogenesis—a strategic roadmap. Nat Rev Neurol. 2021;17(4):231–42.

    Article 

    Google Scholar
     

  • Hamed SA, Abdellah MM, El-Melegy N. Blood levels of trace elements, electrolytes, and oxidative stress/antioxidant systems in epileptic patients. J Pharmacol Sci. 2004;96(4):465–73.

    CAS 
    Article 

    Google Scholar
     

  • Hamed SA, Hamed EA, Hamdy R, Nabeshima T. Vascular risk factors and oxidative stress as independent predictors of asymptomatic atherosclerosis in adult patients with epilepsy. Epilepsy Res. 2007;74(2–3):183–92.

    CAS 
    Article 

    Google Scholar
     

  • Nemade ST, Melinkeri RR. Oxidative and antioxidative status in epilepsy. Pravara Med Rev. 2010;2(4):8–10.


    Google Scholar
     

  • Saad K, Hammad E, Hassan AF, Badry R. Trace element, oxidant, and antioxidant enzyme values in blood of children with refractory epilepsy. Int J Neurosci. 2014;124(3):181–6.

    CAS 
    Article 

    Google Scholar
     

  • Dal-Pizzol F, Klamt F, Vianna MM, Schröder N, Quevedo J, Benfato MS, et al. Lipid peroxidation in hippocampus early and late after status epilepticus induced by pilocarpine or kainic acid in Wistar rats. Neurosci Lett. 2000;291(3):179–82.

    CAS 
    Article 

    Google Scholar
     

  • Ben-Menachem E, Kyllerman M, Marklund S. Superoxide dismutase and glutathione peroxidase function in progressive myoclonus epilepsies. Epilepsy Res. 2000;40(1):33–9.

    CAS 
    Article 

    Google Scholar
     

  • Sudha K, Rao AV, Rao A. Oxidative stress and antioxidants in epilepsy. Clin Chim Acta. 2001;303(1–2):19–24.

    CAS 
    Article 

    Google Scholar
     

  • Verrotti A, Basciani F, Trotta D, Pomilio MP, Morgese G, Chiarelli F. Serum copper, zinc, selenium, glutathione peroxidase and superoxide dismutase levels in epileptic children before and after 1 year of sodium valproate and carbamazepine therapy. Epilepsy Res. 2002;48(1–2):71–5.

    CAS 
    Article 

    Google Scholar
     

  • Peker E, Oktar S, Arı M, Kozan R, Doğan M, Çağan E, et al. Nitric oxide, lipid peroxidation, and antioxidant enzyme levels in epileptic children using valproic acid. Brain Res. 2009;22(1297):194–7.

    Article 

    Google Scholar
     

  • Ercegovac M, Jovic N, Simic T, Beslac-Bumbasirevic L, Sokic D, Djukic T, et al. Byproducts of protein, lipid and DNA oxidative damage and antioxidant enzyme activities in seizure. Seizure. 2010;19(4):205–10.

    Article 

    Google Scholar
     

  • Ethemoglu O, Ay H, Koyuncu I, Gönel A. Comparison of cytokines and prooxidants/antioxidants markers among adults with refractory versus well-controlled epilepsy: a cross-sectional study. Seizure. 2018;1(60):105–9.

    Article 

    Google Scholar
     

  • Cardenas-Rodriguez N, Huerta-Gertrudis B, Rivera-Espinosa L, Montesinos-Correa H, Bandala C, Carmona-Aparicio L, et al. Role of oxidative stress in refractory epilepsy: evidence in patients and experimental models. Int J Mol Sci. 2013;14(1):1455–76.

    Article 

    Google Scholar
     

  • Puttachary S, Sharma S, Stark S, Thippeswamy T. Seizure-induced oxidative stress in temporal lobe epilepsy. Biomed Res Int. 2015;20(2015): 745613. https://doi.org/10.1155/2015/745613.

    CAS 
    Article 

    Google Scholar
     

  • Maes M, Supasitthumrong T, Limotai C, Michelin AP, Matsumoto AK, de Oliveira SL, et al. Increased oxidative stress toxicity and lowered antioxidant defenses in temporal lobe epilepsy and mesial temporal sclerosis: associations with psychiatric comorbidities. Mol Neurobiol. 2020;57:3334–48.

    CAS 
    Article 

    Google Scholar
     

  • Turkdogan D, Toplan S, Karakoc Y. Lipid peroxidation and antioxidative enzyme activities in childhood epilepsy. J Child Neurol. 2002;17(9):673–6.

    Article 

    Google Scholar
     

  • Yiş U, Seçkin E, Kurul SH, Kuralay F, Dirik E. Effects of epilepsy and valproic acid on oxidant status in children with idiopathic epilepsy. Epilepsy Res. 2009;84(2–3):232–7.

    Article 

    Google Scholar
     

  • Iwuozo EU, Obiako OR, Ejiofor JI, Kehinde JA, Abubakar SA. Effect of epilepsy and antiepileptic drugs therapy on erythrocyte malondialdehyde and some antioxidants in persons with epilepsy. West Afr J Med. 2019;36(3):211–6.

    CAS 
    PubMed 

    Google Scholar
     

  • Menon B, Ramalingam K, Kumar RV. Low plasma antioxidant status in patients with epilepsy and the role of antiepileptic drugs on oxidative stress. Ann Indian Acad Neurol. 2014;17(4):398.

    Article 

    Google Scholar
     

  • Grewal GK, Kukal S, Kanojia N, Saso L, Kukreti S, Kukreti R. Effect of oxidative stress on ABC transporters: contribution to epilepsy pharmacoresistance. Molecules. 2017;22(3):365.

    Article 

    Google Scholar
     

  • Martinc B, Grabnar I, Vovk T. The role of reactive species in epileptogenesis and influence of antiepileptic drug therapy on oxidative stress. Curr Neuropharmacol. 2012;10(4):328–43.

    CAS 
    Article 

    Google Scholar
     

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