• Joe E, Ringman JM. Cognitive symptoms of Alzheimer’s disease: clinical management and prevention. BMJ. 2019;367:l6217.

    PubMed 
    Article 

    Google Scholar
     

  • Trevisan K, Cristina-Pereira R, Silva-Amaral D, Aversi-Ferreira TA. Theories of aging and the prevalence of Alzheimer’s disease. Biomed Res Int. 2019;2019:9171424.

    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar
     

  • Jia J, Wei C, Chen S, Li F, Tang Y, Qin W, et al. The cost of Alzheimer’s disease in China and re-estimation of costs worldwide. Alzheimers Dement. 2018;14(4):483–91.

    PubMed 
    Article 

    Google Scholar
     

  • Lin SY, Lin PC, Lin YC, Lee YJ, Wang CY, Peng SW, et al. The clinical course of early and late mild cognitive impairment. Front Neurol. 2022;13:685636.

    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Lotan R, Ganmore I, Livny A, Itzhaki N, Waserman M, Shelly S, et al. Effect of advanced glycation end products on cognition in older adults with type 2 diabetes: results from a pilot clinical trial. JAD. 2021;82(4):1785–95.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Zhang Z, Zhang B, Wang X, Zhang X, Yang QX, Qing Z, et al. Olfactory dysfunction mediates adiposity in cognitive impairment of type 2 diabetes: insights from clinical and functional neuroimaging studies. Diabetes Care. 2019;42(7):1274–83.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Guzmán-Ramos K, Osorio-Gómez D, Bermúdez-Rattoni F. Cognitive impairment in alzheimer’s and metabolic diseases: a catecholaminergic hypothesis. Neuroscience. 2022;S0306–4522(22):00271–8.


    Google Scholar
     

  • Guo M, Kang K, Wang A, Jia J, Zhang J, Wang Y, et al. Association of diabetes status with cognitive impairment in two Chinese rural communities. J Neurol Sci. 2020;415:116894.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Li Y, Teng D, Shi X, Qin G, Qin Y, Quan H, et al. Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: national cross sectional study. BMJ. 2020;369:m997.

    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Hudish LI, Reusch JE, Sussel L. н╡ cell dysfunction during progression of metabolic syndrome to type 2 diabetes. J Clin Invest. 2019;129(10):4001–8.

    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Blázquez E, Hurtado-Carneiro V, LeBaut-Ayuso Y, Velázquez E, García-García L, Gómez-Oliver F, et al. Significance of brain glucose Hypometabolism, altered insulin signal transduction, and insulin resistance in several neurological diseases. Front Endocrinol. 2022;13:873301.

    Article 

    Google Scholar
     

  • Pignatelli J, de Sevilla MEF, Sperber J, Horrillo D, Medina-Gomez G, Aleman IT. Insulin-like growth factor I couples metabolism with circadian activity through hypothalamic orexin neurons. Int J Mol Sci. 2022;23(9):4679.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Kellar D, Craft S. Brain insulin resistance in Alzheimer’s disease and related disorders: mechanisms and therapeutic approaches. Lancet Neurol. 2020;19(9):758–66.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Tumminia A, Vinciguerra F, Parisi M, Frittitta L. Type 2 diabetes mellitus and Alzheimer’s disease: role of insulin Signalling and therapeutic implications. Int J Mol Sci. 2018;19(11):3306.

    PubMed Central 
    Article 
    CAS 

    Google Scholar
     

  • Hoyer S. Glucose metabolism and insulin receptor signal transduction in Alzheimer disease. Eur J Pharmacol. 2004;490(1–3):115–25.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Kandimalla R, Thirumala V, Reddy PH. Is Alzheimer’s disease a type 3 diabetes? A critical appraisal. Biochim Biophys Acta Mol basis Dis. 2017;1863(5):1078–89.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Longde W, Ling Y, Yang H, Yi Z, Yongjun W, Xunming J, et al. Fixed-dose combination treatment after stroke for secondary prevention in China: a national community-based study. Stroke. 2015;46(5):1295–300.

    PubMed 
    Article 
    CAS 

    Google Scholar
     

  • Pinto TCC, Machado L, Bulgacov TM, Rodrigues-Júnior AL, Costa MLG, Ximenes RCC, et al. Is the Montreal cognitive assessment (MoCA) screening superior to the Mini-mental state examination (MMSE) in the detection of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) in the elderly? Int Psychogeriatr. 2019;31(4):491–504.

    PubMed 
    Article 

    Google Scholar
     

  • 2. Classification and Diagnosis of Diabetes. Standards of medical Care in Diabetes-2019. Diabetes Care. 2019;42(Suppl 1):S13–s28.


    Google Scholar
     

  • Priya MM, Amutha A, Pramodkumar TA, Ranjani H, Jebarani S, Gokulakrishnan K, et al. н╡-cell function and insulin sensitivity in Normal glucose-tolerant subjects stratified by 1-hour plasma glucose values. Diabetes Technol Ther. 2016;18(1):29–33.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412–9.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Hashimoto M, Tashiro H, Kobayashi T, Kuroda S, Hamaoka M, Ohdan H. Influence of higher BMI for hepatitis B- and C-related hepatocellular carcinomas. Langenbecks Arch Surg. 2017;402(5):745–55.

    PubMed 
    Article 

    Google Scholar
     

  • Wang J, Liu Y, Zhang L, Li N, Wang C, Gao X, et al. Associations of high sensitivity C-reactive protein levels with the prevalence of asymptomatic intracranial arterial stenosis. Eur J Neurol. 2014;21(3):512–8.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Warren JD, Bamiou DE. Prevention of dementia by targeting risk factors. Lancet. 2018;391(10130):1575.

    PubMed 
    Article 

    Google Scholar
     

  • Kuźma E, Hannon E, Zhou A, Lourida I, Bethel A, Levine DA, et al. Which risk factors causally influence dementia? A systematic review of Mendelian randomization studies. JAD. 2018;64(1):181–93.

    PubMed 
    Article 

    Google Scholar
     

  • Burillo J, Marqués P, Jiménez B, González-Blanco C, Benito M, Guillén C. Insulin resistance and diabetes mellitus in Alzheimer’s disease. Cells. 2021;10(5):1236.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Thankappan S, Sen S, Subramanian S, Sinha P, Purushottam M, Bharath S. Insulin resistance in patients with Alzheimer’s dementia: a controlled study from India. Asian J Psychiatr. 2018;38:33–4.

    PubMed 
    Article 

    Google Scholar
     

  • Hoyer S, Nitsch R. Cerebral excess release of neurotransmitter amino acids subsequent to reduced cerebral glucose metabolism in early-onset dementia of Alzheimer type. J Neural Transm. 1989;75(3):227–32.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Bingham EM, Hopkins D, Smith D, Pernet A, Hallett W, Reed L, et al. The role of insulin in human brain glucose metabolism: an 18fluoro-deoxyglucose positron emission tomography study. Diabetes. 2002;51(12):3384–90.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Anfossi G, Russo I, Doronzo G, Trovati M. Contribution of insulin resistance to vascular dysfunction. Arch Physiol Biochem. 2009;115(4):199–217.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Roussel R, Natali A, Balkau B, Højlund K, Sánchez G, Nolan JJ, et al. Beta-cell function is associated with carotid intima-media thickness independently of insulin resistance in healthy individuals. J Hypertens. 2016;34(4):685–91.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Zhou M, Pan Y, Jing J, Wang Y, Zhao X, Liu L, et al. Association between н╡-cell function estimated by HOMA-н╡ and prognosis of non-diabetic patients with ischaemic stroke. Eur J Neurol. 2018;25(3):549–55.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Nath M, Misra S, Nair P, Kumar P. Carotid intima-media thickness and risk of mild cognitive impairment: a systematic review and meta-analysis. Acta Neurol Scand. 2022;145(2):139–50.

    PubMed 
    Article 

    Google Scholar
     

  • Ojagbemi A, Bello T, Owolabi M, Baiyewu O. Cognitive decline before and after a first-ever stroke in Africans. Acta Neurol Scand. 2021;144(3):266–74.

    PubMed 
    Article 

    Google Scholar
     

  • Biessels GJ, Kamal A, Ramakers GM, Urban IJ, Spruijt BM, Erkelens DW, et al. Place learning and hippocampal synaptic plasticity in streptozotocin-induced diabetic rats. Diabetes. 1996;45(9):1259–66.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Skeberdis VA, Lan J, Zheng X, Zukin RS, Bennett MV. Insulin promotes rapid delivery of N-methyl-D- aspartate receptors to the cell surface by exocytosis. Proc Natl Acad Sci U S A. 2001;98(6):3561–6.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Figlewicz DP, Szot P, Israel PA, Payne C, Dorsa DM. Insulin reduces norepinephrine transporter mRNA in vivo in rat locus coeruleus. Brain Res. 1993;602(1):161–4.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Kopf SR, Baratti CM. Effects of posttraining administration of insulin on retention of a habituation response in mice: participation of a central cholinergic mechanism. Neurobiol Learn Mem. 1999;71(1):50–61.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Craft S, Raman R, Chow TW, Rafii MS, Sun CK, Rissman RA, et al. Safety, efficacy, and feasibility of intranasal insulin for the treatment of mild cognitive impairment and Alzheimer disease dementia: a randomized clinical trial. JAMA Neurol. 2020;77(9):1099–109.

    PubMed 
    Article 

    Google Scholar
     

  • Barone E, Tramutola A, Triani F, Calcagnini S, Di Domenico F, Ripoli C, et al. Biliverdin reductase-a mediates the beneficial effects of intranasal insulin in Alzheimer disease. Mol Neurobiol. 2019;56(4):2922–43.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, et al. The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695–9.

    PubMed 
    Article 

    Google Scholar
     

  • Lee SH, Park SY, Choi CS. Insulin resistance: from mechanisms to therapeutic strategies. Diabetes Metab J. 2022;46(1):15–37.

    PubMed 
    Article 

    Google Scholar
     

  • Wang T, Lu J, Shi L, Chen G, Xu M, Xu Y, et al. Association of insulin resistance and н╡-cell dysfunction with incident diabetes among adults in China: a nationwide, population-based, prospective cohort study. Lancet Diabetes Endocrinol. 2020;8(2):115–24.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Festa A, Haffner SM, Wagenknecht LE, Lorenzo C, Hanley AJ. Longitudinal decline of н╡-cell function: comparison of a direct method vs a fasting surrogate measure: the insulin resistance atherosclerosis study. J Clin Endocrinol Metab. 2013;98(10):4152–9.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Biessels GJ, Despa F. Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications. Nat Rev Endocrinol. 2018;14(10):591–604.

    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

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