• Aytac HM, Oyaci Y, Pehlivan M, Pehlivan S (2021) DNA Methylation Pattern of Gene Promoters of MB-COMT, DRD2, and NR3C1 in Turkish Patients Diagnosed with Schizophrenia

  • Avramopoulos D, Pearce BD, McGrath J, Wolyniec P, Wang R, Eckart N et al (2015) Infection and inflammation in schizophrenia and bipolar disorder: a genome wide study for interactions with genetic variation. PLoS ONE 10(3):e0116696

    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar
     

  • Aytac HM, Yazar MS, Erol A, Pehlivan S (2021) Investigation of inflammation related gene polymorphism of the mannose-binding lectin 2 in schizophrenia and bipolar disorder. Neurosci J 26(4):346–356


    Google Scholar
     

  • Aytac HM, Oyaci Y, Yazar MS, Pehlivan S (2021) Macrophage migration inhibitory factor-173 G/C polymorphism is associated with the age of onset and insight in Schizophrenia in the Turkish population. Neurol Res 43(12):977–984

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Nursal AF, Aytac HM, Ciftci HS, Sila M, Oyaci Y, Pehlivan M et al (2021) TNF-α-308 G/A variant may be associated with bipolar disorder in a Turkish population. Arch Clin Psychiatry (São Paulo) 47:176–179


    Google Scholar
     

  • Aytac HM, Ozdilli K, Tuncel FC, Pehlivan M, Pehlivan S (2020) Tumor necrosis factor-alpha (TNF-α) −238 G/A polymorphism is associated with the treatment resistance and attempted suicide in Schizophrenia. Immunol Investig 51(2):368–380. https://doi.org/10.1080/08820139.2020.1832115

    CAS 
    Article 

    Google Scholar
     

  • Pehlivana S, Aytacb HM, Ciftcia HS, Oyacia Y, Pehlivanc M, Nursal AF (2020) Investigating the eNOS and IFN-γ gene variants susceptible to bipolar disorder or Schizophrenia in a Turkish cohort. Psychiatry Clin Psychopharmacol 30(4):354–361


    Google Scholar
     

  • Aytac HM, Pehlivan S, Pehlivan M, Oyaci Y (2022) Quantitative detection of methylated SOCS-1 in schizophrenia and bipolar disorder considering SOCS-1 -1478CA/del polymorphism and clinical parameters. Irish J Med Sci (1971 -). https://doi.org/10.1007/s11845-022-03030-w

    Article 

    Google Scholar
     

  • Kim Y-K, Jung H-G, Myint A-M, Kim H, Park S-H (2007) Imbalance between pro-inflammatory and anti-inflammatory cytokines in bipolar disorder. J Affect Disord 104(1–3):91–95

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • García-Bueno B, Bioque M, Mac-Dowell KS, Barcones MF, Martínez-Cengotitabengoa M, Pina-Camacho L et al (2014) Pro-/anti-inflammatory dysregulation in patients with first episode of psychosis: toward an integrative inflammatory hypothesis of schizophrenia. Schizophr Bull 40(2):376–387

    PubMed 
    Article 

    Google Scholar
     

  • Reale M, Costantini E, Greig NH (2021) Cytokine imbalance in schizophrenia. From research to clinic: potential implications for treatment. Front Psychiatry. https://doi.org/10.3389/fpsyt.2021.536257

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Arend WP, Malyak M, Guthridge CJ, Gabay C (1998) Interleukin-1 receptor antagonist: role in biology. Annu Rev Immunol 16(1):27–55

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Katila H, Hänninen K, Hurme M (1999) Polymorphisms of the interleukin-1 gene complex in schizophrenia. Mol Psychiatry 4(2):179–181

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Santtila S, Savinainen K, Hurme M (1998) Presence of the IL-1RA allele 2 (IL1RN* 2) is associated with enhanced IL-1beta production in vitro. Scand J Immunol 47(3):195–198

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Hope S, Ueland T, Steen NE, Dieset I, Lorentzen S, Berg AO et al (2013) Interleukin 1 receptor antagonist and soluble tumor necrosis factor receptor 1 are associated with general severity and psychotic symptoms in schizophrenia and bipolar disorder. Schizophr Res 145(1–3):36–42

    PubMed 
    Article 

    Google Scholar
     

  • Kim S, Lee H, Koo H, Kim J, Song J, Kim M et al (2004) Impact of IL-1 receptor antagonist gene polymorphism on schizophrenia and bipolar disorder. Psychiatr Genet 14(3):165–167

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Zanardini R, Bocchio-Chiavetto L, Scassellati C, Bonvicini C, Tura GB, Rossi G et al (2003) Association between IL-1β-511C/T and IL-1RA (86bp) n repeats polymorphisms and schizophrenia. J Psychiatr Res 37(6):457–462

    PubMed 
    Article 

    Google Scholar
     

  • Watanabe Y, Nunokawa A, Kaneko N, Muratake T, Koizumi M, Someya T (2007) Lack of association between the interleukin-1 gene complex and schizophrenia in a Japanese population. Psychiatry Clin Neurosci 61(4):364–369

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Hosseini S, Taheri M, Hosseni-khah Z, Hajilooi M, Mazaheri Z (2013) Influence of IL-1RN intron 2 variable number of tandem repeats (VNTR) polymorphism on bipolar disorder. Neuropsychobiology 67(2):116–121

    PubMed 
    Article 
    CAS 

    Google Scholar
     

  • Kubo M, Yamashita M, Abe R, Tada T, Okumura K, Ransom JT et al (1999) CD28 costimulation accelerates IL-4 receptor sensitivity and IL-4-mediated Th2 differentiation. J Immunol 163(5):2432–2442

    CAS 
    PubMed 

    Google Scholar
     

  • Coffman R, Ohara J, Bond M, Carty J, Zlotnik A, Paul W (1986) B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J Immunol 136(12):4538–4541

    CAS 
    PubMed 

    Google Scholar
     

  • Del Prete G, Maggi E, Parronchi P, Chretien I, Tiri A, Macchia D et al (1988) IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants. J Immunol 140(12):4193–4198

    PubMed 

    Google Scholar
     

  • Mout R, Willemze R, Landegent J (1991) Repeat polymorphisms in the interleukin-4 gene (IL4). Nucleic Acids Res 19(13):3763

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Elghoroury EA, Fadel FI, Farouk H, Elshamaa MF, Kamel S, Kandil D, Mahmoud E (2018) Association of variable number tandem repeats polymorphism in the IL-4 gene with end-stage renal disease in children. Egypt J Med Human Genet 19(3):191–195. https://doi.org/10.1016/j.ejmhg.2017.08.009

    Article 

    Google Scholar
     

  • Munkholm K, Braüner JV, Kessing LV, Vinberg M (2013) Cytokines in bipolar disorder vs. healthy control subjects: a systematic review and meta-analysis. J Psychiatr Res 47(9):1119–1133. https://doi.org/10.1016/j.jpsychires.2013.05.018

    Article 
    PubMed 

    Google Scholar
     

  • Şimşek Ş, Yıldırım V, Çim A, Kaya S (2016) Serum IL-4 and IL-10 levels correlate with the symptoms of the drug-naive adolescents with first episode, early onset schizophrenia. J Child Adolesc Psychopharmacol 26(8):721–726

    PubMed 
    Article 
    CAS 

    Google Scholar
     

  • Association WM (2013) World medical association declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA 310(20):2191–2194

    Article 
    CAS 

    Google Scholar
     

  • Vasudevan R, Norhasniza M, Patimah I (2011) Association of variable number of tandem repeats polymorphism in the IL-4 gene with end-stage renal disease in Malaysian patients. Genet Mol Res 10(2):943–947

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Singh M, Mansuri M, Jadeja S, Marfatia Y, Begum R, Mansuri MS et al (2018) Association of interleukin 1 receptor antagonist intron 2 variable number of tandem repeats polymorphism with vitiligo susceptibility in Gujarat population. Indian J Dermatol Venereol Leprol. https://doi.org/10.4103/ijdvl.IJDVL_1_17

    Article 
    PubMed 

    Google Scholar
     

  • Lee W-C, Wang L-Y (2008) Simple formulas for gauging the potential impacts of population stratification bias. Am J Epidemiol 167(1):86–89

    PubMed 
    Article 

    Google Scholar
     

  • Mata I, Crespo-Facorro B, Pérez-Iglesias R, Carrasco-Marín E, Arranz MJ, Pelayo-Terán JM et al (2006) Association between the interleukin-1 receptor antagonist gene and negative symptom improvement during antipsychotic treatment. Am J Med Genet B Neuropsychiatr Genet 141(8):939–943

    Article 

    Google Scholar
     

  • Chowdari KV, Xu K, Zhang F, Ma C, Li T, Xie BY et al (2001) Immune related genetic polymorphisms and schizophrenia among the Chinese. Hum Immunol 62(7):714–724

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Alvarez-Rodriguez L, Carrasco-Marin E, Lopez-Hoyos M, Mata C, Fernandez-Prieto L, Ruiz-Soto M et al (2009) Interleukin-1RN gene polymorphisms in elderly patients with rheumatic inflammatory chronic conditions: association of IL-1RN* 2/2 genotype with polymyalgia rheumatica. Hum Immunol 70(1):49–54

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Rezaii AA, Hoseinipanah SM, Hajilooi M, Rafiei AR, Shikh N, Haidari M (2009) Interleukin-1 receptor antagonist gene polymorphism and susceptibility to ischemic stroke. Immunol Invest 38(3–4):220–230

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Chourasia D, Achyut B, Mittal S, Mittal RD, Ghoshal UC (2009) Genotypic and functional roles of IL-1B and IL-1RN on the risk of gastroesophageal reflux disease: the presence of IL-1B−511*T/IL-1RN*1 (T1) Haplotype may protect against the disease. Am J Gastroenterol 104(11):2704–2713. https://doi.org/10.1038/ajg.2009.382

    CAS 
    Article 
    PubMed 

    Google Scholar
     

  • Luheshi NM, Kovács KJ, Lopez-Castejon G, Brough D, Denes A (2011) Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues. J Neuroinflammation 8(1):1–5

    Article 
    CAS 

    Google Scholar
     

  • Meisenzahl EM, Rujescu D, Kirner A, Giegling I, Kathmann N, Leinsinger G et al (2001) Association of an interleukin-1β genetic polymorphism with altered brain structure in patients with schizophrenia. Am J Psychiatry 158(8):1316–1319

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Papiol S, Rosa A, Gutierrez B, Martin B, Salgado P, Catalan R et al (2004) Interleukin-1 cluster is associated with genetic risk for schizophrenia and bipolar disorder. J Med Genet 41(3):219–223

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Talaei A, Afzaljavan F, Talaei A (2021) IL-1α, IL-1β and IL-1RN haplotypes are associated with bipolar I disorder and its characteristics: a pilot case-control study. Meta Gene 30:100977

    CAS 
    Article 

    Google Scholar
     

  • Papiol S, Molina V, Desco M, Rosa A, Reig S, Sanz J et al (2008) Gray matter deficits in bipolar disorder are associated with genetic variability at interleukin-1 beta gene (2q13). Genes Brain Behav 7(7):796–801

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Kalkan G, Karakus N, Baş Y, Takçı Z, Özuğuz P, Ateş Ö et al (2013) The association between Interleukin (IL)-4 gene intron 3 VNTR polymorphism and alopecia areata (AA) in Turkish population. Gene 527(2):565–569

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Basol N, Celik A, Karakus N, Ozsoy SD, Yigit S (2014) The evaluation of angiotensin-converting enzyme (ACE) gene I/D and IL-4 gene intron 3 VNTR polymorphisms in coronary artery disease. In Vivo 28(5):983–987

    CAS 
    PubMed 

    Google Scholar
     

  • Basol N, Inanir A, Yigit S, Karakus N, Kaya SU (2013) High association of IL-4 gene intron 3 VNTR polymorphism with diabetic peripheral neuropathy. J Mol Neurosci 51(2):437–441

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Yigit S, Inanir A, Tekcan A, Tural E, Ozturk GT, Kismali G et al (2014) Significant association of interleukin-4 gene intron 3 VNTR polymorphism with susceptibility to knee osteoarthritis. Gene 537(1):6–9

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Karakus N, Yigit S, Kurt GS, Cevik B, Demir O, Ates O (2013) Association of interleukin (IL)-4 gene intron 3 VNTR polymorphism with multiple sclerosis in Turkish population. Hum Immunol 74(9):1157–1160

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Kalkan G, Yigit S, Karakus N, Baş Y, Seçkin HY (2013) Association between interleukin 4 gene intron 3 VNTR polymorphism and recurrent aphthous stomatitis in a cohort of Turkish patients. Gene 527(1):207–210

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Pérez-Suárez TG, Gutiérrez-Robledo LM, Ávila-Funes JA, Acosta JL, Escamilla-Tilch M, Padilla-Gutiérrez JR et al (2016) VNTR polymorphisms of the IL-4 and IL-1RN genes and their relationship with frailty syndrome in Mexican community-dwelling elderly. Aging Clin Exp Res 28(5):823–832

    PubMed 
    Article 

    Google Scholar
     

  • Bid H, Konwar R, Agrawal C, Banerjee M (2008) Association of IL-4 and IL-1RN (receptor antagonist) gene variants and the risk of type 2 diabetes mellitus: a study in the north Indian population. Indian J Med Sci 62(7):259–266

    PubMed 
    Article 

    Google Scholar
     

  • Paunio T, Ekelund J, Varilo T, Parker A, Hovatta I, Turunen JA et al (2001) Genome-wide scan in a nationwide study sample of schizophrenia families in Finland reveals susceptibility loci on chromosomes 2q and 5q. Hum Mol Genet 10(26):3037–3048

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Schwab S, Hallmayer J, Albus M, Lerer B, Eckstein G, Borrmann M et al (2000) A genome-wide autosomal screen for schizophrenia susceptibility loci in 71 families with affected siblings: support for loci on chromosome 10p and 6. Mol Psychiatry 5(6):638–649

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Schwarz MJ, Krönig H, Riedel M, Dehning S, Douhet A, Spellmann I et al (2006) IL-2 and IL-4 polymorphisms as candidate genes in schizophrenia. Eur Arch Psychiatry Clin Neurosci 256(2):72–76

    PubMed 
    Article 

    Google Scholar
     

  • Jun TY, Lee KU, Pae CU, Chae JH, Bahk WM, Kim KS et al (2003) Polymorphisms of interleukin-4 promoter and receptor gene for schizophrenia in the Korean population. Psychiatry Clin Neurosci 57(3):283–288

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Brietzke E, Stertz L, Fernandes BS, Kauer-Sant’Anna M, Mascarenhas M, Vargas AE et al (2009) Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder. J Affect Disord 116(3):214–217

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Modabbernia A, Taslimi S, Brietzke E, Ashrafi M (2013) Cytokine alterations in bipolar disorder: a meta-analysis of 30 studies. Biol Psychiat 74(1):15–25

    CAS 
    PubMed 
    Article 

    Google Scholar
     

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