Introduction Acute myeloid leukemia (AML) is an aggressive hematopoietic cancer characterized by blocked differentiation of myeloid lineage [1–3]. Due to risk stratification-directed therapy, treatment outcomes with a 5-year survival rates…

Introduction Prodromal alterations in vital parameters help identify clinical deterioration through early changes, often preceding adverse events (Goldhill et al., 1999; Buist et al., 2004; Cuthbertson et al., 2007; DeVita…

In neurocritical care, severe neuroinflammatory conditions and systematic inflammatory storms can occur in central nervous system infection-induced encephalitis, meningitis, or pyogenic brain infections. Systematic inflammatory conditions are observed in severe…

Introduction Vitamins are organic molecules required for the proper functioning of human metabolism. In particular, vitamins A, E and C display antioxidant properties against free radicals, which are known to…

Animals and experimental setup All of the studies performed were approved by the United States Veterans Affairs Animal Component of Research Protocol (ACORP). Additionally, Lexington VA Vivarium is accredited by…

1 Introduction Severe acute pancreatitis (SAP) accounts for 15%-20% of acute pancreatitis (AP), and the mortality is up to 30% (Forsmark et al., 2016). Infection of necrotic pancreatic tissue is one…

Introduction Acute lymphoblastic leukemia (ALL), particularly B-cell lineage ALL (B-ALL), which has been the most prevalent childhood tumor, is a malignant disease characterized by uncontrolled proliferation of immature lymphoid cells…

Centre and ethics This is a single-centre, noninterventional, retrospective analysis of clinical data. The local Ethics Committee approved the study, and informed consent was waived due to the retrospective nature…

Introduction Oxidative stress is an imbalance between the production of cell-damaging free radicals and the body’s ability to neutralize them (1, 2). Oxidative stress exerts a series of adverse effects…

Introduction Patients hospitalized with acute myocardial infarction (AMI) have an increased risk of gastrointestinal bleeding (GIB) because of the possibility of stress-related gastrointestinal mucosal erosion or ulcers and the need…