Tag: amyotrophic

Slow motor neurons resist pathological TDP-43 and mediate motor recovery in the rNLS8 model of amyotrophic lateral sclerosis – Acta Neuropathologica Communications

Mice As described previously [37, 42], rNLS8 mice were generated by crossing animals expressing the tetracycline transactivator (tTA) protein under the control of the human NEFH promoter with a second…

The distribution and function of GDE2, a regulator of spinal motor neuron survival, are disrupted in Amyotrophic Lateral Sclerosis – Acta Neuropathologica Communications

Animals Mice were bred and maintained in accordance with approved Johns Hopkins University Institutional Animal Care and Use Committee protocols. Gde2 heterozygous (Gde2±) mice were bred, maintained, and genotyped as…

Peripheral inflammation and neurodegeneration; a potential for therapeutic intervention in Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) – Egyptian Journal of Neurosurgery

Ramanan VK, Saykin AJ. Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer’s disease, Parkinson’s disease, and related disorders. Am J Neurodegener Dis. 2013;2(3):145–75. PubMed  PubMed Central  Google Scholar  Gitler…