Tag: amyotrophic

Frontiers | Longitudinal monitoring of amyotrophic lateral sclerosis by diffusion tensor imaging: power calculations…

Frontiers | Mixed Comparison of Different Exercise Interventions for Function, Respiratory, Fatigue, and Quality of…

Introduction Amyotrophic lateral sclerosis (ALS, OMIM#105400) is a progressive neurological degenerative disorder without effective treatment affecting 1 in 400 individuals worldwide (van Rheenen et al., 2016). With the fast pace…

Introduction Amyotrophic lateral sclerosis (ALS) is a rare, adult-onset neurodegenerative disease characterized by a loss of motor neurons in the cerebral cortex, brainstem, and spinal cord, giving rise to upper…

Introduction Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease characterized by motor neuron axonal degeneration, with an average survival of 3–5 years after symptom onset (Turner et al., 2013). Serum…

Correction: Palliative sedation in amyotrophic lateral sclerosis: results of a nationwide survey among neurologists and palliative care practitioners in Germany Rights and permissions Open Access This article is licensed under…

Mice As described previously [37, 42], rNLS8 mice were generated by crossing animals expressing the tetracycline transactivator (tTA) protein under the control of the human NEFH promoter with a second…

Animals Mice were bred and maintained in accordance with approved Johns Hopkins University Institutional Animal Care and Use Committee protocols. Gde2 heterozygous (Gde2±) mice were bred, maintained, and genotyped as…

Ramanan VK, Saykin AJ. Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer’s disease, Parkinson’s disease, and related disorders. Am J Neurodegener Dis. 2013;2(3):145–75. PubMed  PubMed Central  Google Scholar  Gitler…

Introduction Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease typically characterized by adult-onset dysfunction of both upper and lower motor neurons (MNs). The incidence rates of this fatal disease were…