Tag: Brain

Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity – Molecular Neurodegeneration

Overview of the study Multiple studies have explored the proteomic landscape of the human brain, with the purpose of identifying proteins and pathways differentially altered in AD [16, 29,30,31]. While…

Unraveling axonal mechanisms of traumatic brain injury – Acta Neuropathologica Communications

Cell lines The Human Neural Stem Cells (NSCs) were obtained from GIBCO. They are derived from the NIH approved H9 (WA09) human embryonic stem cell line. They retain their normal…

Stimulation of protein synthesis by optogenetic and chemical induction of excitatory synaptic plasticity in hippocampal somatostatin interneurons – Molecular Brain

First, we established the specificity of puromycin labeling in the SUnSET assay [8, 13] of EYFP-expressing CA1 SOM-INs of acute hippocampal slices obtained from Sstires−Cre;Rosa26lsl−EYFP mice (SOM-EYFP-WT mice) [6] (Additional file…