1 Introduction Drug-induced liver injury (DILI) is a class of adverse drug reactions (ADR) which is an issue in both clinical and research settings. Although DILI can be mild, resolving…

Intracerebral Hemorrhage Intracerebral hemorrhage (ICH) is the second most common type of stroke in the world, accounting for 10–15% of all strokes (Feigin et al., 2009; Steiner et al., 2014;…

Introduction Spinal cord injury (SCI) causes irreversible damage to the nerve tissue of the spinal cord, which results in the loss of motor and sensory functions at and below the…

Introduction Chronic kidney disease (CKD) is a common health concern worldwide, manifesting as chronic kidney structural and functional disorders. The global prevalence of CKD is 13.4%, of which 10.6% of…

Animals, drugs, and drug administration We purchased conventional SPF C56BL/7 mice (6 weeks) from the Experimental Animal Center, Southern University of Science and Technology (SUSTech). All protocols were approved by the…

Introduction Neuroma is a frequent sequela of peripheral nerve injury that can become painful and disabling for the patient. First described in 1811 by Odier (1), neuroma is classified as…

Neuroinflammation is a central feature of traumatic brain injury (TBI; Smith et al., 2013; Lozano et al., 2015), and it is also implicated in neurodegeneration (Chen et al., 2016; Hong…

Introduction Traffic safety continues to be a major health issue (World Health Organization, 2018). The travelling speed of a motor vehicle is a major factor influencing the probability and severity…

Introduction Chondroitin sulfate proteoglycans (CSPGs) are large glycoproteins that have been widely implicated in suppressing axon regrowth after injury to the central nervous system (CNS). They consist of a protein…

1 Introduction Renal ischemia/reperfusion injury (I/R) is one of the unavoidable co-incidences during kidney transplantation or vascular surgery. Tissue ischemia causes multiple series events that progress to cell injury, dysfunction,…