Tag: Molecular

Correlation of plasma cell assessment by phenotypic methods and molecular profiles by NGS in patients with plasma cell dyscrasias – BMC Medical Genomics

Degree of BM involvement by different methods The study included 77 MM, two solitary plasmacytoma seven MGUS and four AL amyloidosis cases. The mean proportion of infiltrating BM plasma cells…

Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity – Molecular Neurodegeneration

Overview of the study Multiple studies have explored the proteomic landscape of the human brain, with the purpose of identifying proteins and pathways differentially altered in AD [16, 29,30,31]. While…

Stimulation of protein synthesis by optogenetic and chemical induction of excitatory synaptic plasticity in hippocampal somatostatin interneurons – Molecular Brain

First, we established the specificity of puromycin labeling in the SUnSET assay [8, 13] of EYFP-expressing CA1 SOM-INs of acute hippocampal slices obtained from Sstires−Cre;Rosa26lsl−EYFP mice (SOM-EYFP-WT mice) [6] (Additional file…