Introduction Stomach adenocarcinoma (STAD) is one of the leading malignancies contributing to the health burden as well as being the third leading cause of cancer deaths worldwide (Bray et al.,…

This Research Topic, Osteoporosis and the Role of Muscle, began as an exploration of the effect bone resorption had on muscle wasting and the contribution of the latter to falls…

The Role of Cdh1 and Cdc20 in Cell Cycle Regulation To ensure a correct DNA-duplication and distribution of chromosomes to the daughter cells, the cell cycle is controlled by a…

Lala P, Chakraborty C (2001) Role of nitric oxide in carcinogenesis and tumour progression. Lancet Oncol. https://doi.org/10.1016/S1470-2045(00)00256-4 Article  PubMed  Google Scholar  Culotta E, Koshland DE (1992) NO news is good…

1. Introduction Degradation is one of most significant bioprocesses of metabolism in almost all forms of life. For most eukaryotic cells, three pathways were discovered to degrade multiple proteins: (1)…

Introduction Obesity and being overweight are pathological conditions characterized by excessive body mass index (BMI) and/or fat mass (1). Overweight is defined as a BMI greater than or equal to…

Oxidative stress plays a critical role in the pathophysiology of various ischemic heart diseases (IHDs) including coronary artery disease and myocardial infarction, and their associated complications such as arrhythmia, heart…

Introduction Brain-derived neurotrophic factor (BDNF) is a small molecule dimer protein, and the main member of the neurotrophic protein family in the brain (Song et al., 2017). BDNF is widely…

1 Introduction Severe acute pancreatitis (SAP) accounts for 15%-20% of acute pancreatitis (AP), and the mortality is up to 30% (Forsmark et al., 2016). Infection of necrotic pancreatic tissue is one…

Introduction Dry eye is a multifactorial ocular surface disease that is characterized by the loss of tear film homeostasis and accompanied by ocular discomfort (1). Tear film instability, hyperosmotic stress,…