Neuroinflammation is a central feature of traumatic brain injury (TBI; Smith et al., 2013; Lozano et al., 2015), and it is also implicated in neurodegeneration (Chen et al., 2016; Hong…
Introduction Brain-derived neurotrophic factor (BDNF) is a small molecule dimer protein, and the main member of the neurotrophic protein family in the brain (Song et al., 2017). BDNF is widely…
1 Introduction Severe acute pancreatitis (SAP) accounts for 15%-20% of acute pancreatitis (AP), and the mortality is up to 30% (Forsmark et al., 2016). Infection of necrotic pancreatic tissue is one…
Highlight 1. MALAT1, LIN28A and Nox4 are upregulated in diabetic nephropathy tissues and high glucose-treated HK-2 cells. 2. MALAT1 directly interacts with LIN28A. 3. LIN28A targets Nox4 to enhance the…
Introduction Female reproductive success depends on ovarian follicular development which is reflected by the differentiation of granulosa cells and oocyte maturation. During the antral follicular developmental stage, somatic cells, especially…
Tamura K, Utsunomiya J, Iwama T, Furuyama J, Takagawa T, Takeda N, Fukuda Y, Matsumoto T, Nishigami T, Kusuhara K, et al. Mechanism of carcinogenesis in familial tumors. Int J…
Gray SG, Mutti L. Immunotherapy for mesothelioma: a critical review of current clinical trials and future perspectives. Transl Lung Cancer Res. 2020;9:S100–19. CAS PubMed PubMed Central Article Google Scholar Disselhorst…
Preparation of MA var. extract In this study, the same extract of FMA var. utilized in our previous study was used [19]. In brief, MA was purchased from Omniherb Co.…
Correction: Estrogen signaling effects on muscle-specific immune responses through controlling the recruitment and function of macrophages and T cells Rights and permissions Open Access This article is licensed under a…
Introduction Colorectal cancer (CRC) is one of the most prevalent malignancies in the digestive system. The incidence of CRC is rising year after year, and CRC ranks third in terms…
Commentary: Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury
Cali M. McEntee, et al.
Neuroinflammation is a central feature of traumatic brain injury (TBI; Smith et al., 2013; Lozano et al., 2015), and it is also implicated in neurodegeneration (Chen et al., 2016; Hong…
The Role of Brain-Derived Neurotrophic Factor Signaling in Central Nervous System Disease Pathogenesis
Shu-Hui Dou, et al.
Introduction Brain-derived neurotrophic factor (BDNF) is a small molecule dimer protein, and the main member of the neurotrophic protein family in the brain (Song et al., 2017). BDNF is widely…
Gut Microbiota-Derived Diaminopimelic Acid Promotes the NOD1/RIP2 Signaling Pathway and Plays a Key Role in the Progression of Severe Acute Pancreatitis
Juying Jiao, et al.
1 Introduction Severe acute pancreatitis (SAP) accounts for 15%-20% of acute pancreatitis (AP), and the mortality is up to 30% (Forsmark et al., 2016). Infection of necrotic pancreatic tissue is one…
LncRNA MALAT1 Aggravates Renal Tubular Injury via Activating LIN28A and the Nox4/AMPK/mTOR Signaling Axis in Diabetic Nephropathy
Panai Song, et al.
Highlight 1. MALAT1, LIN28A and Nox4 are upregulated in diabetic nephropathy tissues and high glucose-treated HK-2 cells. 2. MALAT1 directly interacts with LIN28A. 3. LIN28A targets Nox4 to enhance the…
MicroRNA-574 Impacts Granulosa Cell Estradiol Production via Targeting TIMP3 and ERK1/2 Signaling Pathway
Bo Pan, et al.
Introduction Female reproductive success depends on ovarian follicular development which is reflected by the differentiation of granulosa cells and oocyte maturation. During the antral follicular developmental stage, somatic cells, especially…
Tumor endothelial cell-derived extracellular vesicles contribute to tumor microenvironment remodeling – Cell Communication and Signaling
Tamura K, Utsunomiya J, Iwama T, Furuyama J, Takagawa T, Takeda N, Fukuda Y, Matsumoto T, Nishigami T, Kusuhara K, et al. Mechanism of carcinogenesis in familial tumors. Int J…
Combined treatment with inhibitors of ErbB Receptors and Hh signaling pathways is more effective than single treatment in reducing the growth of malignant mesothelioma both in vitro and in vivo – Journal of Translational Medicine
Gray SG, Mutti L. Immunotherapy for mesothelioma: a critical review of current clinical trials and future perspectives. Transl Lung Cancer Res. 2020;9:S100–19. CAS PubMed PubMed Central Article Google Scholar Disselhorst…
Fermented Mentha arvensis administration provides neuroprotection against transient global cerebral ischemia in gerbils and SH-SY5Y cells via downregulation of the MAPK signaling pathway – BMC Complementary Medicine and Therapies
Preparation of MA var. extract In this study, the same extract of FMA var. utilized in our previous study was used [19]. In brief, MA was purchased from Omniherb Co.…
Correction: Estrogen signaling effects on muscle-specific immune responses through controlling the recruitment and function of macrophages and T cells – Skeletal Muscle
Correction: Estrogen signaling effects on muscle-specific immune responses through controlling the recruitment and function of macrophages and T cells Rights and permissions Open Access This article is licensed under a…
KIFC3 Promotes Proliferation, Migration, and Invasion in Colorectal Cancer via PI3K/AKT/mTOR Signaling Pathway
Huiling Liao, et al.
Introduction Colorectal cancer (CRC) is one of the most prevalent malignancies in the digestive system. The incidence of CRC is rising year after year, and CRC ranks third in terms…