Tag: Translational

Xeno-free induced pluripotent stem cell-derived neural progenitor cells for in vivo applications – Journal of Translational Medicine

Generation and maintenance of NPCs NPCs were generated as previously described [10] with modifications. In detail, 80.000 iPSCs per well were plated on day − 2 on a 12-well plate, coated…

SGLT2 inhibitors improve kidney function and morphology by regulating renal metabolic reprogramming in mice with diabetic kidney disease – Journal of Translational Medicine

Effects of EMPA on biochemical indicators and pathological characteristics in db/db mice The flowchart of the animal experiment is shown in Fig. 1A. Mice in the db/db and EMPA groups had…

Integrated lipidomics and network pharmacology analysis to reveal the mechanisms of berberine in the treatment of hyperlipidemia – Journal of Translational Medicine

Chemicals and reagents BBR (061002, purity > 98%) was obtained from Sichuan Xieli Pharmaceutical Co. Ltd. (Sichuan, China). Serum biochemistry kits for determining the levels of serum total cholesterol (TC), total triglyceride…

TSLP promoting B cell proliferation and polarizing follicular helper T cell as a therapeutic target in IgG4-related disease – Journal of Translational Medicine

Patients Seventy-one newly diagnosed and treatment naïve patients with IgG4-RD fulfilling 2019 classification criteria of American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) for IgG4-RD [22] were enrolled in…

Small and long RNA transcriptome of whole human cerebrospinal fluid and serum as compared to their extracellular vesicle fractions reveal profound differences in expression patterns and impacts on biological processes – Journal of Translational Medicine

Emamzadeh FN, Surguchov A. Parkinson’s disease: biomarkers, treatment, and risk factors. Front Neurosci. 2018;12:612. PubMed  PubMed Central  Article  Google Scholar  Ahmed RM, Paterson RW, Warren JD, Zetterberg H, O’Brien JT,…